Design of a novel class of peptide inhibitors of cyclin-dependent kinase/cyclin activation*

HIGHLIGHTS

• who: Claire Gondeau from the (UNIVERSITY) have published the Article: Design of a Novel Class of Peptide Inhibitors of Cyclin-dependent Kinase/Cyclin Activation*, in the Journal: (JOURNAL) of January/11,/2005
• what: The authors demonstrate that this peptide does not interfere with complex formation but forms stable complexes with CDK2-cyclin A. The authors propose a new strategy to selectively inhibit kinase activity of CDK-cyclin complexes by targeting the protein/protein interface between the two subunits. The authors demonstrate that this peptide inhibits CDK2 kinase activity in a competitive fashion with respect to . . .
  

   

  

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