Design of high avidity and low affinity antibodies for in situ control of antibody drug conjugate targeting

HIGHLIGHTS

• who: Reginald Evans from the DepartmentUniversity of have published the Article: Design of high avidity and low affinity antibodies for in situ control of antibody drug conjugate targeting, in the Journal: Scientific Reports Scientific Reports
• what: In this work, a novel carrier antibody engineered for High Avidity and Low Affinity (HALA) is simulated to determine if it can overcome this limitation by in situ adjustment of competitive blocking in the tumor microenvironment.
• how: Full descriptions of the constants and variables used in the model is defined in Supplementary TABLE S1 and S2. To . . .
  

   

  

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