HIGHLIGHTS
SUMMARY
The former includes numerous stromal cells, such as cancer-associated fibroblasts (CAFs), endothelial cells (ECs), tumor-infiltrating lymphocytes (TILs), myeloid-derived suppressor cells (MDSCs), and tumor-associated macrophages (TAMs). There is anisoverexpression sion of growth factors either on cancer cells or other present cells in the TME to provide of growth factors either on cancer cells or other present cells in the TME to provide the the increasing needs of cancer cells. The nanoparticles were internalized into intra-tumoral cells due to the upregulation of CPP, suggesting these nanoparticles as an effective gene delivery . . .
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