Design of new potent and selective thiophene-based kv1.3 inhibitors and their potential for anticancer activity

HIGHLIGHTS

• who: u0160pela Gubiu010d and colleagues from the Faculty of Pharmacy, University of Ljubljana, Au0161kercu030ceva, Ljubljana, Slovenia have published the paper: Design of New Potent and Selective Thiophene-Based KV1.3 Inhibitors and Their Potential for Anticancer Activity, in the Journal: Cancers 2022, 2595 of /2022/
• what: For the analysis of the data, only the inhibition at the 0 mV step was used.
• how: The authors designed a novel structural class of 1.3 through structural optimization of hit compounds and structure-activity relationship studies. All data were analyzed using pClamp Clampfit 10.4 . . .
  

   

  

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