Design of smart nanodiamonds: introducing ph sensitivity to improve nucleic acid carrier efficiency of diamoplexes

HIGHLIGHTS

  • who: Saniya Alwani et al. from the College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK S N , Canada have published the research work: Design of Smart Nanodiamonds: Introducing pH Sensitivity to Improve Nucleic Acid Carrier Efficiency of Diamoplexes, in the Journal: Pharmaceutics 2022, 14, 1794. of 29/07/2022
  • what: This study provides evidence that the addition of histidine a pH-modulating entity in the functionalization design at an optimized ratio renders high efficiency to the diamoplexes. The work presented below provides a systematic comparison of physicochemical properties, gene binding and cellular interactions . . .

     

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