Design, synthesis, and antiprotozoal evaluation of new promising 2,9-bis[(substituted-aminomethyl)]-4,7-phenyl-1,10-phenanthroline derivatives, a potential alternative scaffold to drug efflux

HIGHLIGHTS

• who: Jean Guillon et al. from the Faculty of Pharmacy, University of Bordeaux, CNRS, INSERM, ARNA, UMR, , Bordeaux, France have published the research: Design, Synthesis, and Antiprotozoal Evaluation of New Promising 2,9-Bis[(substituted-aminomethyl)]-4,7-phenyl-1,10-phenanthroline Derivatives, a Potential Alternative Scaffold to Drug Efflux, in the Journal: Pathogens 2022, 11, 1339. of /2022/
• what: The authors report on their in_vitro antiplasmodial activity against the CQ-sensitive (3D7) and the CQ-resistant (W2) strains of the malaria parasite P. falciparum. The aim of this assay was to evaluate the impact . . .
  

   

  

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