Design, synthesis and biological investigation of 2-anilino triazolopyrimidines as tubulin polymerization inhibitors with anticancer activities

HIGHLIGHTS

  • who: Romeo Romagnoli and collaborators from the Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, Italy have published the research: Design, Synthesis and Biological Investigation of 2-Anilino Triazolopyrimidines as Tubulin Polymerization Inhibitors with Anticancer Activities, in the Journal: Pharmaceuticals 2022, 15, x FOR PEER REVIEW of /2022/
  • what: The clinical success of these three classes of compounds has stimulated intensive research aimed at discovering additional microtubule-targeting drugs with clinical potential . Once the 7-(30,40,50 -trimethoxyphenyl)-[1,2,4]triazol pyrimidine motif was identified as the minimum structural requirement . . .

     

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