Design, synthesis, and characterization of potent, slow-binding inhibitors that are selective for gelatinases*

HIGHLIGHTS

• who: M. Margarida Bernardo from the 84(m, H),-2., (m, H),-1., (m, H),(d, Hz, H),(t, ., Hz, H) have published the research: Design, Synthesis, and Characterization of Potent, Slow-binding Inhibitors That Are Selective for Gelatinases*, in the Journal: (JOURNAL) of January/10,/2002
• what: The authors report herein the synthesis and kinetic characterization of two compounds, 4-(4-phenoxyphenylsulfonyl)butane-1,2-dithiol (compound 1) and 5-(4-phenoxyphenylsulfonyl)pentane1,2-dithiol (compound 2), that are potent and selective gelatinase inhibitors.
• how: MMP-2 has been the subject of . . .
  

   

  

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