Design, synthesis, biological evaluation, and molecular dynamics studies of novel lapatinib derivatives

HIGHLIGHTS

• who: Ahmed Elkamhawy et al. from the ngguk University-Seoul, Goyang, Republic of Korea have published the article: Design, Synthesis, Biological Evaluation, and Molecular Dynamics Studies of Novel Lapatinib Derivatives, in the Journal: (JOURNAL)
• what: The structural modification of the C4 aniline group was the focus of the structure-activity relationship (SAR) research of the quinazoline moiety due to its role in kinase selectivity .
• how: All the obtained data are shown u2206G in Table 8.
• future: As a result new approaches and inhibitory small molecules are still needed for EGFR/HER2 . . .
  

   

  

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