Design, synthesis, molecular modeling, and bioactivity evaluation of 1,10-phenanthroline and prodigiosin (ps) derivatives and their copper(i) complexes against mtor and hdac enzymes as highly potent and effective new anticancer therapeutic drugs

HIGHLIGHTS

  • who: . et al. from the Sungkyunkwan University, South Korea China have published the Article: Design, synthesis, molecular modeling, and bioactivity evaluation of 1,10-phenanthroline and prodigiosin (Ps) derivatives and their Copper(I) complexes against mTOR and HDAC enzymes as highly potent and effective new anticancer therapeutic drugs, in the Journal: (JOURNAL)
  • what: In this study, a series of 1,10-phenanthroline and Prodigiosin (Ps) derivatives consisting of their 2:1 ligand-to-metal copper(I) complexes, as PF6- salts, have been isolated and characterized.

SUMMARY

    The targeted inhibition of HDAC . . .

     

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