Designed peptides as nanomolar cross-amyloid inhibitors acting via supramolecular nanofiber co-assembly

HIGHLIGHTS

• who: Karin Taş from the Assessment of cell damage via the MTT reduction assay Studies on the effects of peptides on the formation of cell-damaging IAPP assemblies were performed in cultured RIN5fm (obtained from TE. Rucinsky at the Washington University Tissue Culture Support Center) in combination with the ThT binding assay and TEM using previously established protocols12, , , . Briefly, cells were cultivated and platted in, well plates as described in ref., . Aliquots of solutions used for the ThT binding assays (see "ThT binding assays") were diluted with cell medium at the indicated incubation time points (, h or . . .
  

   

  

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