Desorption electrospray ionization mass spectrometry imaging techniques depict a reprogramming of energy and purine metabolism in the core brain regions of chronic social defeat stress mice

HIGHLIGHTS

• What: The authors aimed to establish a brain partitioning standard based on intrinsic differences rather than relying on traditional techniques such as HE staining or optical imaging . The authors employed an innovative lipid-based DESI-MSI analysis method with excellent repeatability and distinct boundaries to investigate the metabolites and metabolic pathways in the brains of depressed mice in situ.
• Who: Yulong Song and collaborators from the Male C BL/, J mice (6, weeks old) and , aggressive mice (6, months old) were purchased from Vital River Experimental Animal Co [, ]Ltd. (Beijing, China). The animals were housed . . .
  

   

  

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