Desymmetrization of n-cbz glutarimides through n-heterocyclic carbene organocatalysis

HIGHLIGHTS

• who: Zhouli Hu from the Key LaboratoryTech University, Nanjing, China have published the article: Desymmetrization of N-Cbz glutarimides through N-heterocyclic carbene organocatalysis, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS

SUMMARY

Besides the aforementioned use of NHC as Lewis base catalyst, the asymmetric Bronsted base catalysis with NHC has also made impressive advances, in which NHC can activate 1,3-dicarbonyl compounds, amines, and thiols to realize asymmetric reactions via noncovalent interactions47-51. In sharp contrast to the aforementioned well-developed NHC-activation of aldehydes, enals, and esters, NHC-activation of valuable . . .

 



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