Detachment of hexokinase ii from mitochondria promotes collateral sensitivity in multidrug resistant chronic myeloid leukemia cells

HIGHLIGHTS

  • who: Thais Oliveira from the Instituto Bioquu0131u00b4mica Mu00e9dica Leopoldo Meis, Universidade Federal do Rio Universidade Federal do Rio Janeiro, Rio Janeiro, Brazil have published the article: Detachment of Hexokinase II From Mitochondria Promotes Collateral Sensitivity in Multidrug Resistant Chronic Myeloid Leukemia Cells, in the Journal: (JOURNAL)
  • what: The authors propose that the removal of HK from the mitochondrial membrane would cause a decrease in the production of G6P, which, in turn, would not be available to enter the PPP on a large scale.
  • how: The impact of ABCC1 for CML is less clear . . .

     

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