Detecting gene-gene interactions from gwas using diffusion kernel principal components

HIGHLIGHTS

  • who: Andrew Walakira from the Centre for Functional University of have published the paper: Detecting gene-gene interactions from GWAS using diffusion kernel principal components, in the Journal: (JOURNAL)
  • what: The authors propose a novel approach for robust and computationally efficient epistasis detection. The authors show that the approach is not only able to recover known IBD associated genes but also additional genes of interest linked to this difficult gastrointestinal disease. The authors propose a novel epistasis detection analysis workflow that takes GWAS SNP data as input, develops gene-level summaries via diffusion kernels on . . .

     

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