Determinants of affinity, specificity, and phase separation in a supramodule from post-synaptic density protein

HIGHLIGHTS

• who: Louise Laursen from the of Medical Biochemistry and Microbiology, Uppsala University, BMC Box, Uppsala, Sweden have published the article: Determinants of affinity, specificity, and phase separation in a supramodule from Post-synaptic density protein, in the Journal: (JOURNAL) of October/21,/2022
• what: The authors address general principles that determine the binding affinity and specificity of the PSG supramodule in comparison with PDZ3 alone, by screening 74 putative PDZ binding motifs from proteins present in the PSD . This experiment showed that PSG and FL CC ADGRB1 form reversible LLPS, similarly to the interaction between . . .
  

   

  

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