Determining distinct roles of il-1α through generation of an il-1α knockout mouse with no defect in il-1β expression

HIGHLIGHTS

• who: R.K. Subbarao Malireddi from the Palackyu0301 University Olomouc, Czechia United States have published the article: Determining distinct roles of IL-1u03b1 through generation of an IL-1u03b1 knockout mouse with no defect in IL-1u03b2 expression, in the Journal: (JOURNAL)
• what: To overcome this obstacle, the authors report the generation of a genetic deletion of Il1a in mice using CRISPR technology that did not affect IL-1b induction in response to microbial PAMPs and pathogens. Frontiers in Immunology frontiersin.org 10.3389/fimmu.2022.1068230 in this study and are described below.
 



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