Detrimental and protective action of microglial extracellular vesicles on myelin lesions: astrocyte involvement in remyelination failure

HIGHLIGHTS

• who: Marta Lombardi from the , mm deep). Three days post lesion (dpl), × , EVs, produced by, ., × , microglia and dissolved in , µl of sterile saline, were delivered to the mice with mini-pumps (Alzet osmotic pumps D) at the same coordinates over , days at, ., µl h, delivery rate. To limit EV degradation, minipumps were filled with freshly isolated EVs and implanted within a few hours. Controls were obtained with delivery of saline solution. To examine cell proliferation, we used the thymidine analog, bromo-2-deoxyuridine (BrdU), which is incorporated into DNA during, phase of the cell cycle and remains . . .
  

   

  

  If you want to have access to all the content you need to log in!

  Thanks :)

  Username or E-mail:

  If you don't have an account, you can create one here.