Deubiquitinase catalytic activity of mysm1 is essential in vivo for hematopoiesis and immune cell development

HIGHLIGHTS

• who: Yue Liang from the DepartmentMcGill University Osler, Montreal, QC H G , Canada have published the article: Deubiquitinase catalytic activity of MYSM1 is essential in vivo for hematopoiesis and immune cell development, in the Journal: Scientific Reports Scientific Reports
• what: The authors demonstrate that the loss of MYSM1 DUB catalytic activity in either constitutive or inducible mouse models results in a severe hematologic dysfunction with highly similar phenotypes to the previously characterized Mysm1-/- and Mysm1u0394/u0394 mouse strains. The authors for the first time establish and characterize a mouse strain expressing a catalytically inactive u00adMYSM1D660N . . .
  

   

  

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