HIGHLIGHTS
SUMMARY
Based on gene_expression profile, DLBCL can be classified from the cell of origin (COO) into at least two subtypes, germinal center B-cell-like (GCB) and activated B-cell-like (ABC), while 10-20% of cases remain unclassified. The infiltration levels of naive B cells, memory B cells, resting CD4+ memory T_cells, regulatory T_cells (Tregs), follicular helper T_cells, and activated natural killer (NK) cells were higher in subtype A, while CD8+ T_cells, activated CD4+ memory T_cells, gamma delta T_cells, M1 macrophages, plasma cells had significantly lower infiltration in subtype A compared to those in . . .
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