Development of a cancer-associated fibroblast-related prognostic model in breast cancer via bulk and single-cell rna sequencing

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SUMMARY

    Cancer continues to be a significant worldwide health concern and the main cause of death in China. According to the 2015 China Cancer Epidemiology Report, breast cancer was the most commonly diagnosed cancer among Chinese women in 2015, with an estimated 304,000 new cases, or more than 800 new cases each day. The authors evaluated single cell RNA-seq data from a breast cancer patient and discovered 193 fibroblast markers with highly variable expressions. Using the TCGA-BRCA cohort data set, the authors created a unique CAFrelated signature model with excellent robustness that . . .

     

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