Development of a microphysiological skin-liver- thyroid chip3 model and its application to evaluate the effects on thyroid hormones of topically applied cosmetic ingredients under consumer-relevant conditions

HIGHLIGHTS

SUMMARY

The qualification of the thyrocyte-derived thyroid follicles included testing a known inhibitor of thyroid hormone production, namely methimazole (MMI), which inhibits thyroid peroxidase (a key enzyme involved in thyroid hormone synthesis) (Paul et_al, 2014). As the use of animals for such assessments in Europe has been completely banned since 2013, cosmetic ingredients are now being evaluated using non-animal methods employed in a tiered approach (Desprez et_al, 2018; Alexander-White et_al, 2022). A skin and liver HUMIMIC Chip2 coculture model was used to demonstrate how the dosing frequency and application route impacted the . . .

 



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