HIGHLIGHTS
- who: September and collaborators from the Garrahan Hospital, Argentina University of North Carolina at Chapel have published the Article: Development of a pediatric physiologically-based pharmacokinetic model to support recommended dosing of atezolizumab in children with solid tumors, in the Journal: (JOURNAL)
- what: This approach has been verified with many small_molecules (Huang et_al, 2017; Lutz et_al, 2021; Sinha et_al, 2021; Zhu et_al, 2021) and several therapeutic proteins (Li et_al, 2014; Pan et_al, 2020). The model was calibrated by adjusting the CLadd value to ensure that the simulated plasma atezolizumab concentrations following a single dose of . . .
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