Development of a phagocytosis-dependent gene signature to predict prognosis and response to checkpoint inhibition in clear-cell renal cell carcinoma

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    In ccRCC, the objective response rate of lenvatinib plus pembrolizumab reached 71%, among which Frontiers in Immunology | www.frontiersin.org Co-Expression Module Construction Weighted gene co-expression network analysis (WGCNA) is a system biology method used to describe the correlation patterns between different genes based on expression data. To functionally annotate different gene modules, the Metascape database (http://metascape.org) was utilized to annotate and visualize Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis. Based on the gene signature, the risk score of each patient was calculated by . . .

     

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