Development of a physiologically-based pharmacokinetic model of the rat central nervous system

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• who: Raj K. Singh Badhan et al. from the Manchester Pharmacy School, the University of Manchester, Oxford Road, Manchester, PT, UK have published the article: Development of a Physiologically-Based Pharmacokinetic Model of the Rat Central Nervous System, in the Journal: Pharmaceutics 2014, 6, 97-136 of 26/02/2014
• what: The model yielded reasonable predictions of unbound brain-to-plasma partition ratio (Kpuu brain) and CSF:plasma ratio (CSF:Plasmau) using a series of in vitro permeability and unbound fraction parameters. The model presented allows for simultaneous simulation and analysis of both brain biophase . . .
  

   

  

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