Development of a region-specific physiologically based pharmacokinetic brain model to assess hippocampus and frontal cortex pharmacokinetics

HIGHLIGHTS

• who: Zaril Zakaria and Raj Badhan from the Applied Health Research Group, School of Life and Health Sciences, Aston University, Birmingham , ET, UK have published the research work: Development of a Region-Specific Physiologically Based Pharmacokinetic Brain Model to Assess Hippocampus and Frontal Cortex Pharmacokinetics, in the Journal: (JOURNAL)
• what: The aim of this study is therefore to develop a PBPK model of the rat CNS that considers the whole brain ECF in addition to two regional compartments, namely the frontal cortex and hippocampus, to predict regional brain pharmacokinetics of phenytoin and carbamazepine .
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