Development of highly sensitive digital droplet pcr for detection of ckit mutations in circulating free dna that mediate resistance to tki treatment for gastrointestinal stromal tumor (gist)

HIGHLIGHTS

  • who: Michael Rassner et al. from the Department of Medicine I, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany have published the research work: Development of Highly Sensitive Digital Droplet PCR for Detection of cKIT Mutations in Circulating Free DNA That Mediate Resistance to TKI Treatment for Gastrointestinal Stromal Tumor (GIST), in the Journal: (JOURNAL)
  • what: The authors developed and validated a set of GIST-specific ddPCR assays for the detection of the most frequent cKIT mutations mediating imatinib resistance.

SUMMARY

    Oncogenic mutations in the stem_cell . . .

     

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