HIGHLIGHTS
- who: Frederik Holm Rothemejer and colleagues from the Department of Clinical Medicine, Aarhus University, Aarhus, Denmark have published the paper: Development of HIV-Resistant CAR T Cells by CRISPR/Cas-Mediated CAR Integration into the CCR5 Locus, in the Journal: Viruses 2023, 202 of /2023/
- what: This study provides proof-of-concept for developing HIV-resistant T cells using targeted integration. This approach has been explored in_vivo using either zing finger-nucleases or megaTAL nucleases to induce CCR5 disruption , 2 of 13 NTC03617198. This approach has successfully been used to efficiently disrupt the T_cell receptor . . .
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