Development of immunotherapy for high-grade gliomas: overcoming the immunosuppressive tumor microenvironment

HIGHLIGHTS

  • who: Maria Graciela Castro from the IRCCS Institute of Neurological Sciences of Bologna (ISNB), Italy Northwestern University, United States have published the research work: Development of immunotherapy for high-grade gliomas: Overcoming the immunosuppressive tumor microenvironment, in the Journal: (JOURNAL)
  • what: This study demonstrated that local administration of IL13-PE38QQR is safe . Although the initial CAR T_cell clinical trials were conducted in patients with advanced blood cancers and barriers in the use of CAR T_cells in solid tumors, there remain a large number of preclinical and clinical studies aimed at optimizing this treatment in patients . . .

     

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