Development of nanoluc-targeting protein degraders and a universal reporter system to benchmark tag-targeted degradation platforms

HIGHLIGHTS

• who: Christoph Grohmann from the Department University of have published the paper: Development of NanoLuc-targeting protein degraders and a universal reporter system to benchmark tag-targeted degradation platforms, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors develop and characterise catalytic NanoLuctargeting PROTACs (NanoTACs) that hijack the CRL complexes to trigger proteasomal degradation of NanoLuc-tagged substrates to expand the tTPD repertoire. The authors show that all of the tTPD systems offer up the prospect of selectively and reversibly depleting proteins of interest at will. All graphs in this study have been colour . . .
  

   

  

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