Development of novel isatin-tethered quinolines as anti-tubercular agents against multi and extensively drug-resistant mycobacterium tuberculosis

HIGHLIGHTS

• who: Mohamed A. Abdelrahman and colleagues from the Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Egyptian Russian University have published the research work: Development of Novel Isatin-Tethered Quinolines as Anti-Tubercular Agents against Multi and Extensively Drug-Resistant Mycobacterium tuberculosis, in the Journal: Molecules 2022, 8807 of /2022/
• what: The authors adopted the bioisosteric replacement approach to replace the 3 4 5-trimethoxy-benzylidene moiety in the lead compound IV with the isatin motif a privileged scaffold in the TB discovery to furnish the first series of target Thereafter the isatin motif was N . . .
  

   

  

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