HIGHLIGHTS
- who: Moataz Shaldam et al. from the Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University have published the article: Development of Novel Quinoline-Based Sulfonamides as Selective Cancer-Associated Carbonic Anhydrase Isoform IX Inhibitors, in the Journal: (JOURNAL) of 11/Oct/2021
- how: Analysis of the obtained results showed that grafting the sulfamoyl group at the para-position (13a-c KI s 5.5-25.8 nM) was more beneficial for hCA IX inhibitory activity than the ortho-substitution (9a-d KI s 25.9-65.6 nM) and the meta-substitution (11a-d . . .
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