Development of p-tau differentiated cell model of alzheimer’s disease to screen novel acetylcholinesterase inhibitors

HIGHLIGHTS

• who: Giuseppe Uras et al. from the School of Pharmacy, The University of Nottingham, University Park, Nottingham , RD, UK have published the paper: Development of p-Tau Differentiated Cell Model of Alzheimeru2019s Disease to Screen Novel Acetylcholinesterase Inhibitors, in the Journal: (JOURNAL)
• what: The authors developed and validated a novel cell-based AD model featuring Tau hyperphosphorylation and degenerative neuronal morphology. Using the model the authors evaluated the efficacy of three different groups of newly synthesized (AChE) along with a new dual acetylcholinesterase/glycogen synthase kinase 3 inhibitor as potential AD treatment on differentiated SH . . .
  

   

  

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