Development of sesamol carbamate-l-phenylalanine prodrug targeting l-type amino acid transporter1 (lat1) as a potential antiproliferative agent against melanoma

HIGHLIGHTS

• who: Tarapong Srisongkram et al. from the Division of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen, Thailand have published the research: Development of Sesamol Carbamate-L-Phenylalanine Prodrug Targeting L-Type Amino Acid Transporter1 (LAT1) as a Potential Antiproliferative Agent against Melanoma, in the Journal: (JOURNAL)
• what: To date, there has been no report on using the prodrug approach for LAT1-mediated delivery of melanoma treatment molecules; hence, this study aimed to demonstrate and apply the LAT1-mediated delivery prodrug approach to improve intracellular sesamol uptake and, as a consequence, antiproliferation . . .
  

   

  

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