Development, testing, parameterisation, and calibration of a human pbk model for the plasticiser, di (2-ethylhexyl) adipate (deha) using in silico , in vitro and human biomonitoring data

HIGHLIGHTS

• who: March and collaborators from the Johns Hopkins University, United States have published the research: Development, testing, parameterisation, and calibration of a human PBK model for the plasticiser, di (2-ethylhexyl) adipate (DEHA) using in silico , in vitro and human biomonitoring data, in the Journal: (JOURNAL)
• what: The model was parameterized using in_vitro and in silico methods such as, measured intrinsic hepatic clearance scaled from in_vitro to in_vivo and predicted octanol-water PC (Log Pow) values which, in turn, were used to predict parameters such as plasma unbound fraction and tissue:blood partition_coefficients (PCs). A . . .
  

   

  

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