HIGHLIGHTS
SUMMARY
Due to the ongoing global COVID-19 pandemic, which can also affect directly or indirectly the developing and adult human brain (Iadecola et_al, 2020; Shook et_al, 2022), it is at present unclear how the actual numbers of PD cases will develop in the future. The late diagnosis of PD (usually when at least 50% of the SNc DA neurons have already died; Surmeier et_al, 2017; Blesa et_al, 2022), puts forward an urgent need of early diagnostic biomarkers enabling a timely intervention in the expected future rise of PD cases (Balestrino and Schapira, 2020; Chmielarz . . .
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