Developmental regulation of a novel outwardly rectifying mechanosensitive anion channel in caenorhabditis elegans *

HIGHLIGHTS

• who: Michael Christensen from the potential, and/or the activity of other transport pathwaysC. elegans oocytes express a Cl, ortholog encoded by clh-3. Meiotic cell cycle progression activates the channel. Activation of , in turn appears to modulate the function of neighboring somatic cells that control oocyte ovulation (34). Knockout of the Cl, gene in mice causes male sterility and a profound disruption of male germ cell development (23). ICl, mec has biophysical characteristics resembling those of the ubiquitous swelling-activated anion current, ICl, swell. The mechanisms by which the ICl, swell channel senses and is activated . . .
  

   

  

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