HIGHLIGHTS
SUMMARY
Acetylcholine (ACh) is a major neuromodulator in the mammalian forebrain that regulates higher brain functions including attention and memory. The authors investigated the regulation of GABAergic gene_expression in forebrain cholinergic neurons in mice throughout development, focusing particularly on neurons in the nucleus basalis, which provides a major cholinergic input to the cortex, and the medial septum, which provides cholinergic input to the hippocampus. The authors found that while a cumulative genetic labeling of GABAergic markers marks all cholinergic neurons as GABAreleasing, only a subset of cholinergic neurons express GABAergic markers at a particular time . . .
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