Dexamethasone inhibited angiotensin ii and its receptors to reduce sepsis-induced lung and kidney injury in rats

HIGHLIGHTS

• What: The authors centrifuged tissue homogenate for 30 min at 12000 rpm/min and 4˚C and the supernatant was isolated and preserved in a freezer at -80˚C. During the experiment, the supernatant and serum extracted as above were used for NO detection by nitrate the reductase method, and the operation was strictly in accordance with the instructions. The study showed that the serum levels of TNF-α and MIP-1α in the LPS groups were higher than those in the control groups, suggesting that inflammatory reaction occurred in the LPS groups during sepsis.
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