Dexmedetomidine attenuates ferroptosis-mediated renal ischemia/reperfusion injury and in fl ammation by inhibiting acsl4 via α 2-ar

HIGHLIGHTS

• who: Dexmedetomidine Attenuates Ferroptosis et al. from the Research Institute (IRCCS), Italy University of Houston, United States have published the research: Dexmedetomidine Attenuates Ferroptosis-Mediated Renal Ischemia/Reperfusion Injury and In fl ammation by Inhibiting ACSL4 via u03b1 2-AR, in the Journal: (JOURNAL)
• what: The authors focused on the ACSL4, a key isozyme for polyunsaturated_fatty_acids metabolism that dictates ferroptosis sensitivity. The results of this study demonstrated that the GPX4 activity decreased, COX2 expression increased, and ferroptosis occurred during renal I/R injury in mice.
• how: The mitochondrial morphological feature of ferroptosis was . . .
  

   

  

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