Dgat2 partially compensates for lipid-induced er stress in human dgat1-deficient intestinal stem cells[s]

HIGHLIGHTS

• who: Jorik M. van Rijn from the DivisionUniversity, Utrecht, The Netherlands have published the Article: DGAT2 partially compensates for lipid-induced ER stress in human DGAT1-deficient intestinal stem cells[S], in the Journal: (JOURNAL)
• what: The authors show an unexpected role for DGAT2 in lipid metabolism, as DGAT2 partially compensates for LD formation and lipotoxicity in DGAT1-deficient intestinal stem_cells. The authors show that (un)saturated FA-induced lipotoxicity is mediated by ER stress. More importantly, the authors demonstrate that overexpression of DGAT2 fully compensates for the loss of DGAT1 in organoids, indicating that . . .
  

   

  

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