HIGHLIGHTS
- who: Markus Sauer from the University of have published the research work: DHX36 prevents the accumulation of translationally inactive mRNAs with G4-structures in untranslated regions, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
- what: Taken together, the authors propose the model that DHX36 loss results in the formation of rG4s and other structures on target mRNAs that stabilize them, but also trigger a stress response rendering them translationally incompetent, possibly by sequestration in SGs or their precursors/seeds. In the FH-DHX36-E335A PARCLIP the authors recovered additional AU-rich clusters in addition to the . . .
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