Diabetes downregulates the antimicrobial peptide psoriasin and increases e. coli burden in the urinary bladder

HIGHLIGHTS

• who: Soumitra Mohanty from the Study participants and collection of human serum, plasma and urine exfoliated cells The study was approved by the Regional Ethics Committee, Stockholm and performed in accordance with the Helsinki DeclarationInformed consent was obtained from all patients and volunteers participating in the study. Adult individuals with prediabetes (ethics permission, :300), diabetes mellitus (DM) and non-diabetic controls (ethics permissions, (amendment, ), (amendment, ), (amendment, )) were included. Patients and volunteers with ongoing UTI, any antimicrobial treatment or estrogen supplementation, were excluded. Venous blood glucose, HbA1c and urine creatinine were analysed in Karolinska University Hospital Laboratory using . . .
  

   

  

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