Diarylation of thiazolopyrimidines by laccase and their in vitro evaluation as antitumor agents

HIGHLIGHTS

• who: Mansour Shahedi from the DepartmentBeheshti University have published the Article: Diarylation of thiazolopyrimidines by laccase and their in vitro evaluation as antitumor agents, in the Journal: Scientific Reports Scientific Reports
• what: Result and discussion Here the authors report a new strategy for the synthesis of gem-dicatechols through laccase-catalyzed oxidation of catechol to ortho-quinone and subsequent nucleophilic attack of active methylene carbon.
• how: Showed that compounds with ketone substituents on the 12-dihydropyrimidine ring had better yields than ester substituents on this ring 4 h (73%) and 4c (82%) versus . . .
  

   

  

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