HIGHLIGHTS
- who: Lavorato and Manuela from the Department University of have published the article: Dichloroacetate improves mitochondrial function, physiology, and morphology in FBXL4 disease models, in the Journal: (JOURNAL)
- what: In contrast, the homozygous Fbxl4-/- zebrafish and C. elegans models used in the study had high survival rates, allowing for multiple long-term physiological studies. The authors demonstrated that DCA increases CS activity in both C. elegans and patient fibroblasts, which the authors postulate may be an adaptation to PDK inhibition to increase TCA cycle anaplerosis. While it remains uncertain whether DCA may be a good . . .
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