Dietary spermidine improves cognitive function

HIGHLIGHTS

  • who: Sabrina Schroeder from the University of Graz, Graz, Austria have published the research: Dietary spermidine improves cognitive function, in the Journal: (JOURNAL) of April/13,/2021
  • what: The authors show that dietary spermidine passes the blood-brain barrier mice and increases hippocampal eIF5A hypusination and mitochondrial function. The authors show large-scale prospective data linking higher dietary spermidine intake with a reduced risk for cognitive impairment humans. In flies, the authors show that SPD-enhanced respiration requires functional autophagy and, specifically, the mitophagy mediators Pink1 and Parkin. SPD enhances hippocampal mitochondrial respiration capacity Given . . .

     

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