Differential activity of candidate microbicides against early steps of hiv-1 infection upon complement virus opsonization

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  • who: Mohammad-Ali Jenabian et al. from the The gp120-interacting plant lectins Hippeastrum hybrid (amaryllis) (HHA) and Galanthus nivalis (snowdrop) (GNA) were derived and purified from the bulbs of these plants, as previously described [16]The gp120-interacting sulfated polyvinyl alcohol (PVAS) which inhibits the virus entry, (molecular weight, , Da) was synthesized in the form of its sodium salts by the sulfation of PVA (polyvinyl alcohol) with chlorosulfonic acid in pyridine-dimethylformamide solution [17]. Human lactoferrin (Lf ) [18] which limits the , attachment on dendritic cells by inhibiting virus attachment on heparan sulfate proteoglycans [14] and mannan . . .

     

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