Differential il18 signaling via il18 receptor and na-cl co-transporter discriminating thermogenesis and glucose metabolism regulation

HIGHLIGHTS

• who: Xian Zhang from the (UNIVERSITY) have published the article: Differential IL18 signaling via IL18 receptor and Na-Cl co-transporter discriminating thermogenesis and glucose metabolism regulation, in the Journal: (JOURNAL) of 30/09/2021
• what: The authors show that IL18 signaling in metabolism is regulated at the level of receptor utilization, with preferential role for NCC in brown adipose_tissue (BAT) and dominantly via IL18r in WAT. As the authors summarized in Fig 10, here the authors report the beneficial but divergent roles of IL18 in thermogenesis and in glucose metabolism and insulin sensitivity, although . . .
  

   

  

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