Differential impairment of cerebrospinal fluid synaptic biomarkers in the genetic forms of frontotemporal dementia

HIGHLIGHTS

  • who: Aitana Sogorb-Esteve from the Queen Square Institute of Neurology, London WC N BG, UK have published the Article: Differential impairment of cerebrospinal fluid synaptic biomarkers in the genetic forms of frontotemporal dementia, in the Journal: (JOURNAL)
  • what: The authors investigated a panel of CSF synaptic markers in presymptomatic and symptomatic people with genetic FTD from the GENetic Frontotemporal dementia Initiative (GENFI), hypothesizing that the authors would find differential abnormalities across MAPT, GRN, and C9orf72 mutation carriers. The authors show increased levels of 14-3-3 eta protein in the symptomatic MAPT mutation carriers . . .

     

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