Differential regulation of cardiac excitation-contraction coupling by camp phosphodiesterase subtypes

HIGHLIGHTS

• who: INSERM, UMR-S and Châtenay-Malabry, from the 69, France have published the Article: Differential regulation of cardiac excitation-contraction coupling by cAMP phosphodiesterase subtypes, in the Journal: (JOURNAL) of 13/Dec/2012
• what: Since selective inhibitors of PDE1 and PDE8 are still lacking, the authors focused the attention on PDE2, PDE3, and PDE4 for which selective inhibitors exist. Although PDE2 represents only a few per cents of total hydrolytic activity in ARVMs the authors show here that it regulates basal and b-ARstimulated ECC. This study focused on the role of three . . .
  

   

  

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